Cesium Chloride (CsCl) - High Purity Crystal from Reliable China Suppliers and Factory
Preparation Method
Industrial preparation is mainly through the following ways:
01
Reaction of metallic cesium with hydrochloric acid.
02
Neutralization method with cesium carbonate or cesium hydroxide.
03
Mineral extraction: High-purity CsCl is obtained from pollucite by acid leaching, ion exchange and other steps.
Chemical and Physical Properties
High-density solution
The density of saturated CsCl solution can reach 1.9 g/cm³, which is often used for density gradient centrifugation separation of biological samples (such as DNA purification).
Ionic conductivity
Molten CsCl is an excellent ion conductor and is used for high-temperature electrolyte research.
Optical properties
CsCl crystals have a wide light transmission range (0.2~55 μm) and can be used for infrared spectrometer prisms.
Radioactive applications
Gamma-ray sources of Cs-137** (half-life 30.17 years) are widely used in medical and industrial irradiation.
Main Applications
1. Molecular biology
- Density gradient centrifugation is used to separate nucleic acids and virus particles.
- As a buffer component for PCR reactions.
2. Nuclear medicine
- Cs-131 (half-life 9.7 days) is used for brachytherapy of prostate cancer.
3. Materials science
- Preparation of cesium vapor for photoelectric tubes and ion thrusters.
- Synthesis of functional materials with CsCl-type structures (such as perovskite solar cell precursors).
Basic Research
- Used to prepare optical lattices in ultracold atom experiments.
- Study the phase transition behavior of ionic crystals (transformed to NaCl-type structure at high temperature).
Safety and Storage
CsCl is moderately toxic (LD₅₀ rat oral administration is about 2300 mg/kg), but radioactive isotopes need to be strictly protected. Storage needs to be moisture-proof and sealed to avoid contact with strong oxidants. Radioactive materials such as Cs-137 need to be managed in accordance with nuclear safety regulations.
Conclusion
Due to its unique crystal structure, excellent solubility and diverse isotopic characteristics, cesium chloride occupies an important position in the fields of life sciences, nuclear technology and functional materials. Its applications extend from basic research to high-tech, reflecting the multifunctional value of alkali metal halides.
Frequently Asked Questions (FAQ)
Q: How is Cesium Chloride (CsCl) prepared industrially?
A: Industrial preparation is mainly achieved through the reaction of metallic cesium with hydrochloric acid, the neutralization of cesium carbonate or cesium hydroxide, or by mineral extraction from pollucite using acid leaching and ion exchange.
Q: Why is Cesium Chloride used in DNA purification?
A: Saturated CsCl solutions have a very high density (up to 1.9 g/cm³), making them ideal for density gradient centrifugation to separate biological samples like DNA and virus particles.
Q: What role does CsCl play in nuclear medicine?
A: Isotope Cs-131, derived from cesium, is used in brachytherapy for the treatment of prostate cancer, while Cs-137 is utilized as a gamma-ray source for medical and industrial irradiation.
Q: What are the optical applications of Cesium Chloride?
A: Because CsCl crystals possess a wide light transmission range (0.2 to 55 μm), they are highly suitable for manufacturing prisms used in infrared spectrometers.
Q: What safety precautions should be taken when handling Cesium Chloride?
A: CsCl is moderately toxic (oral LD₅₀ in rats is approx. 2300 mg/kg) and must be stored in a moisture-proof, sealed container away from strong oxidants. Radioactive isotopes like Cs-137 must be strictly managed under nuclear safety regulations.